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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN14
All Species:
21.82
Human Site:
S591
Identified Species:
48
UniProt:
Q15678
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15678
NP_005392.2
1187
135261
S591
S
H
R
H
K
Y
V
S
G
S
S
P
D
L
V
Chimpanzee
Pan troglodytes
XP_001171329
1187
135241
S591
S
H
R
H
K
Y
V
S
G
S
S
P
D
L
V
Rhesus Macaque
Macaca mulatta
XP_001106167
1187
135194
S591
S
H
R
H
K
Y
I
S
G
S
S
P
D
L
V
Dog
Lupus familis
XP_849236
1187
134903
S591
S
H
R
H
K
Y
V
S
G
S
S
P
D
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q62130
1189
135012
S591
S
H
R
H
K
Y
V
S
G
S
S
P
D
L
V
Rat
Rattus norvegicus
Q62728
1175
133393
R597
S
N
P
D
L
I
T
R
R
V
H
H
S
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511302
1193
135259
S596
R
H
K
Y
V
S
G
S
S
P
D
L
V
T
R
Chicken
Gallus gallus
XP_419419
1191
135566
G596
H
R
H
K
Y
V
S
G
S
S
P
D
L
V
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001339962
834
94004
T286
E
V
S
E
P
L
V
T
A
R
R
P
H
M
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
T478
S
C
D
E
K
S
W
T
P
S
M
A
C
T
S
Sea Urchin
Strong. purpuratus
XP_796215
1318
147575
E602
E
H
I
Q
T
T
E
E
Y
I
T
A
K
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
95.6
N.A.
91.5
53.7
N.A.
87.9
84.9
N.A.
32.8
N.A.
N.A.
N.A.
24.7
34.5
Protein Similarity:
100
99.7
99.5
97.2
N.A.
95.6
70.7
N.A.
92.1
91.5
N.A.
48.1
N.A.
N.A.
N.A.
42
51.7
P-Site Identity:
100
100
93.3
100
N.A.
100
6.6
N.A.
13.3
6.6
N.A.
13.3
N.A.
N.A.
N.A.
20
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
26.6
13.3
N.A.
26.6
N.A.
N.A.
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
10
0
0
19
0
0
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
10
10
0
0
0
0
0
0
10
10
46
0
0
% D
% Glu:
19
0
0
19
0
0
10
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
10
46
0
0
0
0
0
0
% G
% His:
10
64
10
46
0
0
0
0
0
0
10
10
10
0
10
% H
% Ile:
0
0
10
0
0
10
10
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
10
10
55
0
0
0
0
0
0
0
10
0
0
% K
% Leu:
0
0
0
0
10
10
0
0
0
0
0
10
10
55
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
10
0
10
0
0
0
10
10
10
55
0
0
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
10
10
46
0
0
0
0
10
10
10
10
0
0
0
10
% R
% Ser:
64
0
10
0
0
19
10
55
19
64
46
0
10
0
10
% S
% Thr:
0
0
0
0
10
10
10
19
0
0
10
0
0
19
10
% T
% Val:
0
10
0
0
10
10
46
0
0
10
0
0
10
19
46
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
10
46
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _